Leonardo and Karai: A Starcrossed TMNT Story is a special event focused on the love-hate relationship between Leonardo and Karai.
- Leonardo (Josh Keaton) - represents Romeo
- Karai (Kim Mai Guest) - represents Juliet
- Raphael (Keith Ferguson)
- Michelangelo (Matt Hill)
- Donatello (Corey Feldman)
- Master Splinter (Jeff Bennett) - represents Romeo's loving father
- April O'Neill (Jodi Benson)
- Casey Jones (Brian Bloom)
- Shredder (Keith Szrabajka) - represents Juliet's hateful father
- Bebop and Rocksteady (Gary Anthony Williams and J.B. Blanc) - Shredder's lacking henchmen
A mission starts when Shredder makes plans to control the Sewer lines with probes to find the Turtles, but Bebop and Rocksteady informs that Karai had went out on her own. This in infuriates the Shredder, but then sees it as an opportunity.