In a game set in the Arkhamverse, Amanda Waller assembled the Suicide Squad to destroy the Society of Sin's ultimate weapon.
- Suicide Squad:
- Floyd Lawton/Deadshot (Neal McDonough)
- Digger Harkness/Captain Boomerang (Greg Ellis)
- Harleen Quinzel/Harley Quinn (Tara Strong)
- Ben Turner/Bronze Tiger (Gary Sturgis) - A former assassin for the League of Assassins
- Slade Wilson/Deathstroke (Mark Rolston) - leaves to become a foe for the Teen Titans.
- Angelo Bend/Angleman (Bryton James) - killed when ?Chemo activates his bomb.
- Nacht/Night and Nebel/Fog (Piotr Michael and Lucie Pohl) - German brother-sister duo, killed when they aid Dr, Strange with the Weapon.
- Arthur Light/Dr. Light (Arnold Vosloo) - becomes Deathstroke's partner in crime.
- Komand’r/Blackfire (Pauley Perrette) - is seen part of the Tamaranian Royal Family returned to Tamaran.
- Lisa Snart/Golden Glider (Kari Wahlgren) - Captain Cold's sister.
- Bruce Wayne/Batman (Kevin Conroy) - Playable in a subplot involving Dr. Achiles Milo's involvement with Cadmus.
- Amanda Waller (CCH Pounder) - has the Squad in a mission to ???
- General Wade Eiling (Wade Williams) - ???
- Colonel Rick Flagg (Adam Baldwin) - ???
- Hugo Strange (Corey Burton) - the main antagonist, ???, his goal is to ???, after being ???, he is seen in a post credit scene making a deal with Ra’s al Ghul
- Dr. Achilles Milo (Brent Spiner) - a boss in the Level: “???”, ???
- Chemo (Grant Moninger) - a boss in the Level: “???”, ???
- Brotherhood of Evil: an evil organization in Paris, where they ???
- Brain (Corey Burton) - a boss in the Level: “???”, ???
- Monsieur Mallah (Ross Douglas) - a boss in the Level: “???”, ???
- Madame Rouge (Danika McKeller) - a boss in the Level: “???”, ???
- General Immortus (Dwight Shultz) - a boss in the Level: “???”, ???
Level 1: ???Edit
Level 2: ???Edit
Level 3: ???Edit
Level 4: ???Edit
Level 5: ???Edit
Level 6: ???Edit
Level 7: ???Edit
Level 8: ???Edit
Level 9: ???Edit
- This Video game is Rated M for mature, due to the fact that Waller blows up their heads, only in the shadows.
- The story takes place between Arkham Origins and Assault on Arkham.