In the fourth and final installment of the trilogy, the Avengers are now semi retired, as they find themselves to their future, but they find themselves working with their children from the future, as Baron Zemo and the Masters of Evil strike.
- Avengers from the future:
- James Rogers (Noah Crawford) - Son to Steve Rogers and Natalia Romanov
- Torunn Thorsdottir (Brenna O'Brien) - Daughter to Thor and Lady Sif
- Azari (Dempsey Pappion) - Son of T'Challa and Storm
- Henry Pym, Jr. (Aidan Drummond) - Son of his single mother, Janet Pym
- Francis Barton (Adrian Petriw) - Son to Clint Barton and Bobbi Morse
- Avengers from the present:
- Tony Stark/Iron Man (Marc Woorden for Present day, Tom Kane from the future) - He is recording the history of the Avengers.
- Steve Rogers/Captain America (Justin Gross) - having married and settled down with Natalia, he gave birth to his son, James Rogers
- Natalia Romanov-Rogers/Black Widow (Olivia d'Abo) - James' mother and Steve's wife
- Thor (David Boat) - when his father died from an incident relating to Surtur, he returns as King of Asgard, as he marries Lady Sif, and gives birth to his daughter, Torunn
- T'Challa/Black Panther (Jeffrey D. Sams) - marries Ororo and gives birth to his son, Azari
- Clint Barton/Hawkeye (Nathan Keyes) - marries Bobbi and gives birth to Francis
- Janet Pym/Wasp (Grey Griffin) - having been pregnant since Hank died, she gives birth to Henry Pym, Jr. fast with help from technology so she doesn't suffer a miscarriage
- Ororo Munroe/Storm (Kristen Williamson) - newfound queen of Wakanda, wife to T'Challa and mother to Azari
- Bobbi Morse-Barton/Mockingbird (Keri Russell) - Clint's newfound wife and mother to Francis
- Lady Sif (Maria Canals) - Thor's wife and Queen of Asgard, and mother to Torunn
- Bruce Banner/Hulk (Michael McKean/Fred Tatasciore) - ???
- Nick Fury (Andre Ware) - ???
- Betty Ross (Nan McNimera) - ???
- Clay Quartermain (Nick Chunlind) - ???
- Jane Foster (Alison Mack) - ???
- Masters of Evil: ???
- Baron Zemo (Oded Fherr) - the main antagonist, his goal is to ???
- Emil Blonsky/Abominaion (French Stewart) - the secondary antagonist, ???
- Anton Vanko/Crimson Dynamo (Dee Bradley Baker) - the tertiary antagonist, ???
- Amora the Enchantress (Claudia Black) - the quaternary antagonist, ???
- David Cannon/Whirlwind (Maurice LaMarche) - the quinary antagonist, ???
- Klaw (Jeff Bennett) - ???
- The film is different from the first six issues of Avengers Vol 4 1-6:
- The Masters of Evil replace Kang and Ultron as the main antagonists.
- The film is rated PG for ???